Drug interactions
Gentamicin + Letibotulinumtoxina
Severity: Moderate
Gentamicin and Letibotulinumtoxina: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aminoglycosides have intrinsic neuromuscular blocking activity and can add to the weakness caused by botulinum toxin. This may produce excessive or spreading muscle weakness, including swallowing or breathing difficulty.
What this interaction means in plain words
Gentamicin and Letibotulinumtoxina can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive impairment of neuromuscular transmission, with aminoglycosides reducing presynaptic acetylcholine release and botulinum toxin blocking its release.
What to do
Avoid giving gentamicin around the time of botulinum toxin injection where possible. If both are needed, monitor for generalized weakness, dysphagia and respiratory compromise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gentamicin
- Cidofovir + Gentamicin Contraindicated
- Adefovir + Gentamicin Major
- Amikacin + Gentamicin Major
- Amlodipine-hydrochlorothiazide-valsartan + Gentamicin Major
- Amphotericin b deoxycholate + Gentamicin Major
- Amphotericin b + Gentamicin Major
Frequently asked questions
Can I take Gentamicin with Letibotulinumtoxina?
MediHelp rates the interaction as moderate. Gentamicin and Letibotulinumtoxina can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aminoglycosides have intrinsic neuromuscular blocking activity and can add to the weakness caused by botulinum toxin. This may produce excessive or spreading muscle weakness, including swallowing or breathing difficulty.
How serious is the interaction between Gentamicin and Letibotulinumtoxina?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid giving gentamicin around the time of botulinum toxin injection where possible. If both are needed, monitor for generalized weakness, dysphagia and respiratory compromise.
What other medicines interact with Gentamicin?
MediHelp also lists interactions of Gentamicin with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Gentamicin page.
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