Drug interactions
Gentamicin + Meclofenamate
Severity: Moderate
Gentamicin and Meclofenamate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as meclofenamate reduce renal prostaglandin-dependent blood flow and may decrease gentamicin clearance, raising aminoglycoside levels and nephrotoxicity risk. This is most likely in dehydrated, elderly or renally impaired patients.
What this interaction means in plain words
Gentamicin and Meclofenamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID-induced reduction in renal perfusion and glomerular filtration may increase aminoglycoside exposure and renal injury.
What to do
Monitor serum creatinine and gentamicin concentrations, and prefer a non-NSAID analgesic if renal risk is high.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gentamicin
- Cidofovir + Gentamicin Contraindicated
- Adefovir + Gentamicin Major
- Amikacin + Gentamicin Major
- Amlodipine-hydrochlorothiazide-valsartan + Gentamicin Major
- Amphotericin b deoxycholate + Gentamicin Major
- Amphotericin b + Gentamicin Major
Frequently asked questions
Can I take Gentamicin with Meclofenamate?
MediHelp rates the interaction as moderate. Gentamicin and Meclofenamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs such as meclofenamate reduce renal prostaglandin-dependent blood flow and may decrease gentamicin clearance, raising aminoglycoside levels and nephrotoxicity risk. This is most likely in dehydrated, elderly or renally impaired patients.
How serious is the interaction between Gentamicin and Meclofenamate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and gentamicin concentrations, and prefer a non-NSAID analgesic if renal risk is high.
What other medicines interact with Gentamicin?
MediHelp also lists interactions of Gentamicin with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Gentamicin page.
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