Drug interactions
Gentamicin + Mestranol
Severity: Minor
Gentamicin and Mestranol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral gentamicin could in theory alter gut flora and reduce estrogen recycling. Systemic gentamicin has no meaningful effect on gut flora, and loss of contraceptive efficacy has not been documented.
What this interaction means in plain words
Gentamicin and Mestranol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical reduction in gut bacterial deconjugation of estrogens and enterohepatic recirculation; not established for aminoglycosides.
What to do
No routine action is needed. Advise backup contraception only if vomiting or severe diarrhea occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Gentamicin
- Cidofovir + Gentamicin Contraindicated
- Adefovir + Gentamicin Major
- Amikacin + Gentamicin Major
- Amlodipine-hydrochlorothiazide-valsartan + Gentamicin Major
- Amphotericin b deoxycholate + Gentamicin Major
- Amphotericin b + Gentamicin Major
Frequently asked questions
Can I take Gentamicin with Mestranol?
MediHelp rates the interaction as minor. Gentamicin and Mestranol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oral gentamicin could in theory alter gut flora and reduce estrogen recycling. Systemic gentamicin has no meaningful effect on gut flora, and loss of contraceptive efficacy has not been documented.
How serious is the interaction between Gentamicin and Mestranol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed. Advise backup contraception only if vomiting or severe diarrhea occurs.
What other medicines interact with Gentamicin?
MediHelp also lists interactions of Gentamicin with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Gentamicin page.
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