Drug interactions
Gentamicin + Methoxyflurane
Severity: Major
Gentamicin and Methoxyflurane: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methoxyflurane releases fluoride during metabolism and can cause dose-related renal toxicity, and gentamicin is also nephrotoxic. Together they increase the risk of acute kidney injury.
What this interaction means in plain words
Gentamicin and Methoxyflurane can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive nephrotoxicity from fluoride-mediated tubular injury and aminoglycoside tubular toxicity.
What to do
Avoid the combination where possible and keep methoxyflurane exposure minimal. Monitor serum creatinine and gentamicin levels, and ensure hydration.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Gentamicin
- Cidofovir + Gentamicin Contraindicated
- Adefovir + Gentamicin Major
- Amikacin + Gentamicin Major
- Amlodipine-hydrochlorothiazide-valsartan + Gentamicin Major
- Amphotericin b deoxycholate + Gentamicin Major
- Amphotericin b + Gentamicin Major
Frequently asked questions
Can I take Gentamicin with Methoxyflurane?
MediHelp rates the interaction as major. Gentamicin and Methoxyflurane can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Methoxyflurane releases fluoride during metabolism and can cause dose-related renal toxicity, and gentamicin is also nephrotoxic. Together they increase the risk of acute kidney injury.
How serious is the interaction between Gentamicin and Methoxyflurane?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and keep methoxyflurane exposure minimal. Monitor serum creatinine and gentamicin levels, and ensure hydration.
What other medicines interact with Gentamicin?
MediHelp also lists interactions of Gentamicin with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Gentamicin page.
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