Drug interactions
Gentamicin + Neomycin po
Severity: Major
Gentamicin and Neomycin po: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral neomycin is poorly absorbed in normal gut, but absorption can occur with damaged mucosa or renal impairment. Combined with gentamicin it can add to nephrotoxicity, ototoxicity and neuromuscular blockade.
What this interaction means in plain words
Gentamicin and Neomycin po can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive aminoglycoside toxicity to kidney and cochlea.
What to do
Avoid combining where possible. If necessary, monitor renal function, gentamicin levels and hearing, particularly in renal impairment or inflamed bowel.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Gentamicin
- Cidofovir + Gentamicin Contraindicated
- Adefovir + Gentamicin Major
- Amikacin + Gentamicin Major
- Amlodipine-hydrochlorothiazide-valsartan + Gentamicin Major
- Amphotericin b deoxycholate + Gentamicin Major
- Amphotericin b + Gentamicin Major
Frequently asked questions
Can I take Gentamicin with Neomycin po?
MediHelp rates the interaction as major. Gentamicin and Neomycin po can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Oral neomycin is poorly absorbed in normal gut, but absorption can occur with damaged mucosa or renal impairment. Combined with gentamicin it can add to nephrotoxicity, ototoxicity and neuromuscular blockade.
How serious is the interaction between Gentamicin and Neomycin po?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible. If necessary, monitor renal function, gentamicin levels and hearing, particularly in renal impairment or inflamed bowel.
What other medicines interact with Gentamicin?
MediHelp also lists interactions of Gentamicin with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Gentamicin page.
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