Drug interactions
Gentamicin + Olmesartan
Severity: Moderate
Gentamicin and Olmesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Angiotensin receptor blockers can reduce glomerular filtration, especially with volume depletion, which may raise gentamicin exposure and nephrotoxicity risk. Potassium disturbances may also occur if renal function declines.
What this interaction means in plain words
Gentamicin and Olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gentamicin belongs to Anti Bacterial; Olmesartan belongs to Cardiovascular.
Why it happens
Angiotensin II receptor blockade lowers glomerular filtration pressure, which may reduce aminoglycoside clearance and add to renal injury risk.
What to do
Monitor serum creatinine, potassium and gentamicin levels, and maintain hydration. Consider holding olmesartan if renal function deteriorates.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gentamicin
- Cidofovir + Gentamicin Contraindicated
- Adefovir + Gentamicin Major
- Amikacin + Gentamicin Major
- Amlodipine-hydrochlorothiazide-valsartan + Gentamicin Major
- Amphotericin b deoxycholate + Gentamicin Major
- Amphotericin b + Gentamicin Major
Other interactions of Olmesartan
- Aliskiren + Olmesartan Contraindicated
- Olmesartan + Sparsentan Contraindicated
- Aldesleukin + Olmesartan Major
- Amifostine + Olmesartan Major
- Amiloride + Olmesartan Major
- Amlodipine-benazepril + Olmesartan Major
Frequently asked questions
Can I take Gentamicin with Olmesartan?
MediHelp rates the interaction as moderate. Gentamicin and Olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Angiotensin receptor blockers can reduce glomerular filtration, especially with volume depletion, which may raise gentamicin exposure and nephrotoxicity risk. Potassium disturbances may also occur if renal function declines.
How serious is the interaction between Gentamicin and Olmesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine, potassium and gentamicin levels, and maintain hydration. Consider holding olmesartan if renal function deteriorates.
What other medicines interact with Gentamicin?
MediHelp also lists interactions of Gentamicin with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Gentamicin page.
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