Drug interactions
Gentamicin + Peramivir
Severity: Moderate
Gentamicin and Peramivir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Peramivir is eliminated mainly by the kidneys, and gentamicin can cause nephrotoxicity. If renal function declines, peramivir exposure may rise.
What this interaction means in plain words
Gentamicin and Peramivir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Aminoglycoside-induced renal impairment may reduce renal clearance of peramivir.
What to do
Monitor renal function and adjust the peramivir dose according to creatinine clearance if function declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gentamicin
- Cidofovir + Gentamicin Contraindicated
- Adefovir + Gentamicin Major
- Amikacin + Gentamicin Major
- Amlodipine-hydrochlorothiazide-valsartan + Gentamicin Major
- Amphotericin b deoxycholate + Gentamicin Major
- Amphotericin b + Gentamicin Major
Frequently asked questions
Can I take Gentamicin with Peramivir?
MediHelp rates the interaction as moderate. Gentamicin and Peramivir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Peramivir is eliminated mainly by the kidneys, and gentamicin can cause nephrotoxicity. If renal function declines, peramivir exposure may rise.
How serious is the interaction between Gentamicin and Peramivir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and adjust the peramivir dose according to creatinine clearance if function declines.
What other medicines interact with Gentamicin?
MediHelp also lists interactions of Gentamicin with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Gentamicin page.
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