Drug interactions
Gentamicin + Perindopril
Severity: Moderate
Gentamicin and Perindopril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors can reduce glomerular filtration, particularly in volume depletion, and gentamicin is nephrotoxic. Together they may increase the risk of renal impairment and aminoglycoside accumulation.
What this interaction means in plain words
Gentamicin and Perindopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gentamicin belongs to Anti Bacterial; Perindopril belongs to Cardiovascular.
Why it happens
Additive renal risk from ACE inhibitor-reduced glomerular perfusion plus direct aminoglycoside tubular toxicity.
What to do
Monitor creatinine, potassium and gentamicin levels, ensure adequate hydration, and consider temporarily holding perindopril in acute illness.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gentamicin
- Cidofovir + Gentamicin Contraindicated
- Adefovir + Gentamicin Major
- Amikacin + Gentamicin Major
- Amlodipine-hydrochlorothiazide-valsartan + Gentamicin Major
- Amphotericin b deoxycholate + Gentamicin Major
- Amphotericin b + Gentamicin Major
Other interactions of Perindopril
- Aliskiren + Perindopril Contraindicated
- Perindopril + Protein a column Contraindicated
- Perindopril + Sacubitril / valsartan Contraindicated
- Perindopril + Sacubitril-valsartan Contraindicated
- Amifostine + Perindopril Major
- Amiloride + Perindopril Major
Frequently asked questions
Can I take Gentamicin with Perindopril?
MediHelp rates the interaction as moderate. Gentamicin and Perindopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors can reduce glomerular filtration, particularly in volume depletion, and gentamicin is nephrotoxic. Together they may increase the risk of renal impairment and aminoglycoside accumulation.
How serious is the interaction between Gentamicin and Perindopril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor creatinine, potassium and gentamicin levels, ensure adequate hydration, and consider temporarily holding perindopril in acute illness.
What other medicines interact with Gentamicin?
MediHelp also lists interactions of Gentamicin with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Gentamicin page.
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