Drug interactions
Gentamicin + Sacubitril / valsartan
Severity: Moderate
Gentamicin and Sacubitril / valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valsartan can reduce glomerular filtration, especially in volume-depleted patients, and gentamicin is nephrotoxic and renally eliminated. Combined use may increase the risk of acute kidney injury and aminoglycoside accumulation.
What this interaction means in plain words
Gentamicin and Sacubitril / valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Angiotensin receptor blockade lowers efferent arteriolar tone and GFR, adding to aminoglycoside tubular toxicity.
What to do
Monitor serum creatinine, potassium and gentamicin levels, and ensure adequate hydration. Consider temporarily holding sacubitril/valsartan if renal function deteriorates.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gentamicin
- Cidofovir + Gentamicin Contraindicated
- Adefovir + Gentamicin Major
- Amikacin + Gentamicin Major
- Amlodipine-hydrochlorothiazide-valsartan + Gentamicin Major
- Amphotericin b deoxycholate + Gentamicin Major
- Amphotericin b + Gentamicin Major
Frequently asked questions
Can I take Gentamicin with Sacubitril / valsartan?
MediHelp rates the interaction as moderate. Gentamicin and Sacubitril / valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Valsartan can reduce glomerular filtration, especially in volume-depleted patients, and gentamicin is nephrotoxic and renally eliminated. Combined use may increase the risk of acute kidney injury and aminoglycoside accumulation.
How serious is the interaction between Gentamicin and Sacubitril / valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine, potassium and gentamicin levels, and ensure adequate hydration. Consider temporarily holding sacubitril/valsartan if renal function deteriorates.
What other medicines interact with Gentamicin?
MediHelp also lists interactions of Gentamicin with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Gentamicin page.
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