Drug interactions
Gentamicin + Salsalate
Severity: Moderate
Gentamicin and Salsalate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salsalate is a salicylate NSAID that can lower renal prostaglandin-dependent perfusion. With nephrotoxic gentamicin this may increase the risk of renal injury and aminoglycoside accumulation.
What this interaction means in plain words
Gentamicin and Salsalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID-related reduction in renal perfusion adds to aminoglycoside tubular toxicity.
What to do
Monitor serum creatinine and gentamicin levels, maintain hydration, and avoid prolonged combined use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gentamicin
- Cidofovir + Gentamicin Contraindicated
- Adefovir + Gentamicin Major
- Amikacin + Gentamicin Major
- Amlodipine-hydrochlorothiazide-valsartan + Gentamicin Major
- Amphotericin b deoxycholate + Gentamicin Major
- Amphotericin b + Gentamicin Major
Frequently asked questions
Can I take Gentamicin with Salsalate?
MediHelp rates the interaction as moderate. Gentamicin and Salsalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salsalate is a salicylate NSAID that can lower renal prostaglandin-dependent perfusion. With nephrotoxic gentamicin this may increase the risk of renal injury and aminoglycoside accumulation.
How serious is the interaction between Gentamicin and Salsalate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and gentamicin levels, maintain hydration, and avoid prolonged combined use.
What other medicines interact with Gentamicin?
MediHelp also lists interactions of Gentamicin with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Gentamicin page.
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