Drug interactions
Gentamicin + Streptozocin
Severity: Major
Gentamicin and Streptozocin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Streptozocin commonly causes dose-related renal toxicity, and gentamicin adds nephrotoxic and ototoxic risk. Together they may cause more severe or earlier kidney injury.
What this interaction means in plain words
Gentamicin and Streptozocin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive proximal tubular toxicity.
What to do
Avoid concurrent use if possible; otherwise monitor serum creatinine, electrolytes and urinalysis closely and use gentamicin level-guided dosing.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Gentamicin
- Cidofovir + Gentamicin Contraindicated
- Adefovir + Gentamicin Major
- Amikacin + Gentamicin Major
- Amlodipine-hydrochlorothiazide-valsartan + Gentamicin Major
- Amphotericin b deoxycholate + Gentamicin Major
- Amphotericin b + Gentamicin Major
Frequently asked questions
Can I take Gentamicin with Streptozocin?
MediHelp rates the interaction as major. Gentamicin and Streptozocin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Streptozocin commonly causes dose-related renal toxicity, and gentamicin adds nephrotoxic and ototoxic risk. Together they may cause more severe or earlier kidney injury.
How serious is the interaction between Gentamicin and Streptozocin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use if possible; otherwise monitor serum creatinine, electrolytes and urinalysis closely and use gentamicin level-guided dosing.
What other medicines interact with Gentamicin?
MediHelp also lists interactions of Gentamicin with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Gentamicin page.
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