Drug interactions
Gentamicin + Ticarcillin
Severity: Moderate
Gentamicin and Ticarcillin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
In vitro, ticarcillin can bind and inactivate gentamicin, and this is most relevant in patients with severe renal impairment where drug half-lives are long. This may reduce aminoglycoside levels and efficacy, particularly in samples or mixed solutions.
What this interaction means in plain words
Gentamicin and Ticarcillin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Chemical inactivation of the aminoglycoside by the beta-lactam, enhanced when clearance is prolonged in renal failure.
What to do
Do not mix in the same syringe or infusion line, and give at separate sites or times. In renal impairment, monitor gentamicin levels and clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gentamicin
- Cidofovir + Gentamicin Contraindicated
- Adefovir + Gentamicin Major
- Amikacin + Gentamicin Major
- Amlodipine-hydrochlorothiazide-valsartan + Gentamicin Major
- Amphotericin b deoxycholate + Gentamicin Major
- Amphotericin b + Gentamicin Major
Frequently asked questions
Can I take Gentamicin with Ticarcillin?
MediHelp rates the interaction as moderate. Gentamicin and Ticarcillin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. In vitro, ticarcillin can bind and inactivate gentamicin, and this is most relevant in patients with severe renal impairment where drug half-lives are long. This may reduce aminoglycoside levels and efficacy, particularly in samples or mixed solutions.
How serious is the interaction between Gentamicin and Ticarcillin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not mix in the same syringe or infusion line, and give at separate sites or times. In renal impairment, monitor gentamicin levels and clinical response.
What other medicines interact with Gentamicin?
MediHelp also lists interactions of Gentamicin with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Gentamicin page.
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