Drug interactions
Gentamicin + Typhoid vaccine live
Severity: Moderate
Gentamicin and Typhoid vaccine live: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral live typhoid vaccine (Ty21a) contains viable attenuated bacteria that must replicate in the gut to induce immunity. Antibacterial agents active against Salmonella typhi can reduce vaccine organism viability and blunt the immune response. Parenteral gentamicin has poor gut exposure, so the effect is likely small, but the vaccine labeling advises avoiding antibacterials around dosing.
What this interaction means in plain words
Gentamicin and Typhoid vaccine live can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Antibacterial activity may kill the attenuated live vaccine strain, reducing colonization and immunogenicity.
What to do
Delay oral live typhoid vaccination until antibiotic therapy is finished, typically at least 3 days after the last dose per labeling. Revaccinate if the vaccine was given during antibiotic therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gentamicin
- Cidofovir + Gentamicin Contraindicated
- Adefovir + Gentamicin Major
- Amikacin + Gentamicin Major
- Amlodipine-hydrochlorothiazide-valsartan + Gentamicin Major
- Amphotericin b deoxycholate + Gentamicin Major
- Amphotericin b + Gentamicin Major
Frequently asked questions
Can I take Gentamicin with Typhoid vaccine live?
MediHelp rates the interaction as moderate. Gentamicin and Typhoid vaccine live can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral live typhoid vaccine (Ty21a) contains viable attenuated bacteria that must replicate in the gut to induce immunity. Antibacterial agents active against Salmonella typhi can reduce vaccine organism viability and blunt the immune response. Parenteral gentamicin has poor gut exposure, so the effect is likely small, but the vaccine labeling advises avoiding antibacterials around dosing.
How serious is the interaction between Gentamicin and Typhoid vaccine live?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Delay oral live typhoid vaccination until antibiotic therapy is finished, typically at least 3 days after the last dose per labeling. Revaccinate if the vaccine was given during antibiotic therapy.
What other medicines interact with Gentamicin?
MediHelp also lists interactions of Gentamicin with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Gentamicin page.
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