Drug interactions
Gilteritinib + Isoniazid
Severity: Moderate
Gilteritinib and Isoniazid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gilteritinib is cleared mainly by CYP3A4, and isoniazid may modestly reduce this clearance. Higher gilteritinib exposure could increase QT prolongation, differentiation syndrome-related events, and hepatic or other toxicity. The inhibition by isoniazid is weaker than that of classic strong inhibitors, so the effect is likely smaller.
What this interaction means in plain words
Gilteritinib and Isoniazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gilteritinib belongs to Oncology; Isoniazid belongs to Anti Bacterial.
Why it happens
Isoniazid weakly to moderately inhibits CYP3A4, which may reduce gilteritinib metabolism.
What to do
Monitor ECG (QTc), liver tests and electrolytes during coadministration. Interrupt or reduce the gilteritinib dose if serious toxicity appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isoniazid
Other interactions of Gilteritinib
- Gilteritinib + Pimozide Contraindicated
- Amiodarone + Gilteritinib Major
- Amisulpride + Gilteritinib Major
- Amitriptyline + Gilteritinib Major
- Anagrelide + Gilteritinib Major
- Apalutamide + Gilteritinib Major
Frequently asked questions
Can I take Gilteritinib with Isoniazid?
MediHelp rates the interaction as moderate. Gilteritinib and Isoniazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gilteritinib is cleared mainly by CYP3A4, and isoniazid may modestly reduce this clearance. Higher gilteritinib exposure could increase QT prolongation, differentiation syndrome-related events, and hepatic or other toxicity. The inhibition by isoniazid is weaker than that of classic strong inhibitors, so the effect is likely smaller.
How serious is the interaction between Gilteritinib and Isoniazid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG (QTc), liver tests and electrolytes during coadministration. Interrupt or reduce the gilteritinib dose if serious toxicity appears.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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