Drug interactions
Gilteritinib + Lithium
Severity: Moderate
Gilteritinib and Lithium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gilteritinib can prolong the QT interval, and lithium may add to this effect. Patients with leukemia often have electrolyte disturbances or take other QT-prolonging drugs, increasing the arrhythmia risk.
What this interaction means in plain words
Gilteritinib and Lithium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gilteritinib belongs to Oncology; Lithium belongs to Central Nervous System.
Why it happens
Potential additive prolongation of cardiac repolarization.
What to do
Obtain an ECG before starting and during treatment, and keep potassium and magnesium in the normal range. Reduce or interrupt gilteritinib if the QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lithium
- Lithium + Thioridazine Contraindicated
- Lithium + Vandetanib Contraindicated
- Aceclofenac + Lithium Major
- Acemetacin + Lithium Major
- Amisulpride + Lithium Major
- Amlodipine-benazepril + Lithium Major
Other interactions of Gilteritinib
- Gilteritinib + Pimozide Contraindicated
- Amiodarone + Gilteritinib Major
- Amisulpride + Gilteritinib Major
- Amitriptyline + Gilteritinib Major
- Anagrelide + Gilteritinib Major
- Apalutamide + Gilteritinib Major
Frequently asked questions
Can I take Gilteritinib with Lithium?
MediHelp rates the interaction as moderate. Gilteritinib and Lithium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gilteritinib can prolong the QT interval, and lithium may add to this effect. Patients with leukemia often have electrolyte disturbances or take other QT-prolonging drugs, increasing the arrhythmia risk.
How serious is the interaction between Gilteritinib and Lithium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG before starting and during treatment, and keep potassium and magnesium in the normal range. Reduce or interrupt gilteritinib if the QTc becomes markedly prolonged.
What other medicines interact with Lithium?
MediHelp also lists interactions of Lithium with, for example, Thioridazine, Vandetanib, Aceclofenac. The full list is on the Lithium page.
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