Drug interactions
Gilteritinib + Metformin
Severity: Minor
Gilteritinib and Metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gilteritinib may inhibit OCT1 and could alter metformin disposition. The clinical effect is uncertain but could affect glycemic control or lactic acidosis risk.
What this interaction means in plain words
Gilteritinib and Metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Gilteritinib belongs to Oncology; Metformin belongs to Endocrine.
Why it happens
Possible inhibition of OCT1-mediated hepatic uptake of metformin by gilteritinib.
What to do
Monitor blood glucose and renal function during co-therapy. Adjust the metformin dose if glycemic control changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Gilteritinib and Metformin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Gilteritinib
- Gilteritinib + Pimozide Contraindicated
- Amiodarone + Gilteritinib Major
- Amisulpride + Gilteritinib Major
- Amitriptyline + Gilteritinib Major
- Anagrelide + Gilteritinib Major
- Apalutamide + Gilteritinib Major
Other interactions of Metformin
Frequently asked questions
Can I take Gilteritinib with Metformin?
MediHelp rates the interaction as minor. Gilteritinib and Metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Gilteritinib may inhibit OCT1 and could alter metformin disposition. The clinical effect is uncertain but could affect glycemic control or lactic acidosis risk.
How serious is the interaction between Gilteritinib and Metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and renal function during co-therapy. Adjust the metformin dose if glycemic control changes.
What other medicines interact with Gilteritinib?
MediHelp also lists interactions of Gilteritinib with, for example, Pimozide, Amiodarone, Amisulpride. The full list is on the Gilteritinib page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
