Drug interactions
Gilteritinib + Methotrexate
Severity: Moderate
Gilteritinib and Methotrexate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gilteritinib may inhibit BCRP and could raise methotrexate exposure. This may increase myelosuppression, mucositis and hepatic or renal toxicity.
What this interaction means in plain words
Gilteritinib and Methotrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gilteritinib belongs to Oncology; Methotrexate belongs to Oncology.
Why it happens
Inhibition of BCRP-mediated efflux by gilteritinib may reduce methotrexate elimination.
What to do
Monitor blood counts, renal and liver function and methotrexate levels where applicable. Reduce the methotrexate dose if toxicity emerges.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gilteritinib
- Gilteritinib + Pimozide Contraindicated
- Amiodarone + Gilteritinib Major
- Amisulpride + Gilteritinib Major
- Amitriptyline + Gilteritinib Major
- Anagrelide + Gilteritinib Major
- Apalutamide + Gilteritinib Major
Other interactions of Methotrexate
- Acitretin + Methotrexate Contraindicated
- Adenovirus types 4 and 7 live + Methotrexate Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Methotrexate Contraindicated
- Ketorolac + Methotrexate Contraindicated
- Measles mumps and rubella vaccine live + Methotrexate Contraindicated
- Measles mumps and rubella vaccine + Methotrexate Contraindicated
Frequently asked questions
Can I take Gilteritinib with Methotrexate?
MediHelp rates the interaction as moderate. Gilteritinib and Methotrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gilteritinib may inhibit BCRP and could raise methotrexate exposure. This may increase myelosuppression, mucositis and hepatic or renal toxicity.
How serious is the interaction between Gilteritinib and Methotrexate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts, renal and liver function and methotrexate levels where applicable. Reduce the methotrexate dose if toxicity emerges.
What other medicines interact with Gilteritinib?
MediHelp also lists interactions of Gilteritinib with, for example, Pimozide, Amiodarone, Amisulpride. The full list is on the Gilteritinib page.
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