Drug interactions
Gilteritinib + Octreotide
Severity: Moderate
Gilteritinib and Octreotide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gilteritinib is associated with QT prolongation, and octreotide has been linked to QT changes and bradycardia. Combined use may raise the likelihood of serious ventricular arrhythmias.
What this interaction means in plain words
Gilteritinib and Octreotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gilteritinib belongs to Oncology; Octreotide belongs to Endocrine.
Why it happens
Additive QT interval prolongation through pharmacodynamic effects.
What to do
Perform ECG monitoring at baseline and during treatment, and keep potassium and magnesium within normal range. Reduce or stop one agent if QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Octreotide
Other interactions of Gilteritinib
- Gilteritinib + Pimozide Contraindicated
- Amiodarone + Gilteritinib Major
- Amisulpride + Gilteritinib Major
- Amitriptyline + Gilteritinib Major
- Anagrelide + Gilteritinib Major
- Apalutamide + Gilteritinib Major
Frequently asked questions
Can I take Gilteritinib with Octreotide?
MediHelp rates the interaction as moderate. Gilteritinib and Octreotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gilteritinib is associated with QT prolongation, and octreotide has been linked to QT changes and bradycardia. Combined use may raise the likelihood of serious ventricular arrhythmias.
How serious is the interaction between Gilteritinib and Octreotide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Perform ECG monitoring at baseline and during treatment, and keep potassium and magnesium within normal range. Reduce or stop one agent if QTc becomes markedly prolonged.
What other medicines interact with Octreotide?
MediHelp also lists interactions of Octreotide with, for example, Adagrasib, Amisulpride, Arsenic trioxide. The full list is on the Octreotide page.
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