Drug interactions
Gilteritinib + Venlafaxine
Severity: Moderate
Gilteritinib and Venlafaxine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gilteritinib prolongs the QT interval, and venlafaxine has been associated with QT prolongation, particularly at high doses or overdose. Taking both may increase the risk of torsades de pointes.
What this interaction means in plain words
Gilteritinib and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gilteritinib belongs to Oncology; Venlafaxine belongs to Central Nervous System.
Why it happens
Additive QT interval prolongation.
What to do
Monitor ECG and electrolytes, correcting potassium and magnesium, particularly at treatment start. Reassess therapy if QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Venlafaxine
- Isocarboxazid + Venlafaxine Contraindicated
- Methylene blue + Venlafaxine Contraindicated
- Phenelzine + Venlafaxine Contraindicated
- Procarbazine + Venlafaxine Contraindicated
- Rasagiline + Venlafaxine Contraindicated
- Safinamide + Venlafaxine Contraindicated
Other interactions of Gilteritinib
- Gilteritinib + Pimozide Contraindicated
- Amiodarone + Gilteritinib Major
- Amisulpride + Gilteritinib Major
- Amitriptyline + Gilteritinib Major
- Anagrelide + Gilteritinib Major
- Apalutamide + Gilteritinib Major
Frequently asked questions
Can I take Gilteritinib with Venlafaxine?
MediHelp rates the interaction as moderate. Gilteritinib and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gilteritinib prolongs the QT interval, and venlafaxine has been associated with QT prolongation, particularly at high doses or overdose. Taking both may increase the risk of torsades de pointes.
How serious is the interaction between Gilteritinib and Venlafaxine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes, correcting potassium and magnesium, particularly at treatment start. Reassess therapy if QTc becomes markedly prolonged.
What other medicines interact with Venlafaxine?
MediHelp also lists interactions of Venlafaxine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Venlafaxine page.
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