Drug interactions
Ginko biloba + Lomitapide
Severity: Moderate
Ginko biloba and Lomitapide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lomitapide is a sensitive CYP3A4 substrate, and ginkgo may modestly inhibit or modulate CYP3A4. Higher lomitapide exposure could worsen liver enzyme elevations and gastrointestinal adverse effects.
What this interaction means in plain words
Ginko biloba and Lomitapide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ginko biloba belongs to Gastrointestinal Tract; Lomitapide belongs to Cardiovascular.
Why it happens
Possible CYP3A4 inhibition by ginkgo constituents reducing lomitapide metabolism; the effect is inconsistent.
What to do
Avoid ginkgo where possible, and monitor ALT and AST and GI tolerability if used. Do not exceed the labeled lomitapide dose limit for CYP3A4 modulators.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ginko biloba
- Ginko biloba + Ketorolac Major
- Abciximab + Ginko biloba Moderate
- Aceclofenac + Ginko biloba Moderate
- Acemetacin + Ginko biloba Moderate
- Alteplase + Ginko biloba Moderate
- Anagrelide + Ginko biloba Moderate
Other interactions of Lomitapide
- Aprepitant + Lomitapide Contraindicated
- Clarithromycin + Lomitapide Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Efavirenz + Lomitapide Contraindicated
- Ensitrelvir + Lomitapide Contraindicated
Frequently asked questions
Can I take Ginko biloba with Lomitapide?
MediHelp rates the interaction as moderate. Ginko biloba and Lomitapide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lomitapide is a sensitive CYP3A4 substrate, and ginkgo may modestly inhibit or modulate CYP3A4. Higher lomitapide exposure could worsen liver enzyme elevations and gastrointestinal adverse effects.
How serious is the interaction between Ginko biloba and Lomitapide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid ginkgo where possible, and monitor ALT and AST and GI tolerability if used. Do not exceed the labeled lomitapide dose limit for CYP3A4 modulators.
What other medicines interact with Ginko biloba?
MediHelp also lists interactions of Ginko biloba with, for example, Ketorolac, Abciximab, Aceclofenac. The full list is on the Ginko biloba page.
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