Drug interactions
Givinostat + Linagliptin-metformin
Severity: Moderate
Givinostat and Linagliptin-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Givinostat weakly inhibits renal transporters involved in metformin handling, which may slightly raise metformin concentrations. Higher metformin exposure increases the risk of gastrointestinal effects and, rarely, lactic acidosis, particularly in renal impairment.
What this interaction means in plain words
Givinostat and Linagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Givinostat belongs to Miscellaneous; Linagliptin-metformin belongs to Endocrine.
Why it happens
Weak inhibition of renal organic cation transport may reduce metformin renal clearance.
What to do
Monitor renal function and for metformin adverse effects, and consider reducing the metformin dose if tolerability worsens or renal function declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Linagliptin-metformin
Other interactions of Givinostat
- Abiraterone + Givinostat Major
- Amiodarone + Givinostat Major
- Amisulpride + Givinostat Major
- Amitriptyline + Givinostat Major
- Anagrelide + Givinostat Major
- Asenapine + Givinostat Major
Frequently asked questions
Can I take Givinostat with Linagliptin-metformin?
MediHelp rates the interaction as moderate. Givinostat and Linagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Givinostat weakly inhibits renal transporters involved in metformin handling, which may slightly raise metformin concentrations. Higher metformin exposure increases the risk of gastrointestinal effects and, rarely, lactic acidosis, particularly in renal impairment.
How serious is the interaction between Givinostat and Linagliptin-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and for metformin adverse effects, and consider reducing the metformin dose if tolerability worsens or renal function declines.
What other medicines interact with Linagliptin-metformin?
MediHelp also lists interactions of Linagliptin-metformin with, for example, Apalutamide, Carbamazepine, Contrast media. The full list is on the Linagliptin-metformin page.
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