Drug interactions
Givinostat + Maprotiline
Severity: Moderate
Givinostat and Maprotiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can prolong the QT interval, and use together may increase the risk of serious ventricular arrhythmia, particularly with electrolyte disturbance or cardiac disease.
What this interaction means in plain words
Givinostat and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Givinostat belongs to Miscellaneous; Maprotiline belongs to Central Nervous System.
Why it happens
Additive QT prolongation.
What to do
Obtain ECGs at initiation and during concomitant use, and correct potassium and magnesium. Withhold givinostat if QTc exceeds 500 ms or rises markedly from baseline.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Other interactions of Givinostat
- Abiraterone + Givinostat Major
- Amiodarone + Givinostat Major
- Amisulpride + Givinostat Major
- Amitriptyline + Givinostat Major
- Anagrelide + Givinostat Major
- Asenapine + Givinostat Major
Frequently asked questions
Can I take Givinostat with Maprotiline?
MediHelp rates the interaction as moderate. Givinostat and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can prolong the QT interval, and use together may increase the risk of serious ventricular arrhythmia, particularly with electrolyte disturbance or cardiac disease.
How serious is the interaction between Givinostat and Maprotiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain ECGs at initiation and during concomitant use, and correct potassium and magnesium. Withhold givinostat if QTc exceeds 500 ms or rises markedly from baseline.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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