Drug interactions
Givinostat + Memantine-donepezil
Severity: Moderate
Givinostat and Memantine-donepezil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Givinostat prolongs the QT interval, as does donepezil, so the combination may increase arrhythmia risk. Givinostat is also a weak inhibitor of renal transporters, which could modestly raise memantine exposure.
What this interaction means in plain words
Givinostat and Memantine-donepezil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Givinostat belongs to Miscellaneous; Memantine-donepezil belongs to Central Nervous System.
Why it happens
Additive QT prolongation, plus possible givinostat inhibition of renal transport (OCT2/OAT2) reducing memantine clearance.
What to do
Obtain an ECG at initiation and during co-use, and withhold givinostat if QTc exceeds 500 ms or rises more than 60 ms from baseline. Monitor for memantine adverse effects such as dizziness or confusion.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Memantine-donepezil
- Dronedarone + Memantine-donepezil Contraindicated
- Memantine-donepezil + Thioridazine Contraindicated
- Amantadine + Memantine-donepezil Major
- Amiodarone + Memantine-donepezil Major
- Amisulpride + Memantine-donepezil Major
- Amitriptyline + Memantine-donepezil Major
Other interactions of Givinostat
- Abiraterone + Givinostat Major
- Amiodarone + Givinostat Major
- Amisulpride + Givinostat Major
- Amitriptyline + Givinostat Major
- Anagrelide + Givinostat Major
- Asenapine + Givinostat Major
Frequently asked questions
Can I take Givinostat with Memantine-donepezil?
MediHelp rates the interaction as moderate. Givinostat and Memantine-donepezil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Givinostat prolongs the QT interval, as does donepezil, so the combination may increase arrhythmia risk. Givinostat is also a weak inhibitor of renal transporters, which could modestly raise memantine exposure.
How serious is the interaction between Givinostat and Memantine-donepezil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG at initiation and during co-use, and withhold givinostat if QTc exceeds 500 ms or rises more than 60 ms from baseline. Monitor for memantine adverse effects such as dizziness or confusion.
What other medicines interact with Memantine-donepezil?
MediHelp also lists interactions of Memantine-donepezil with, for example, Dronedarone, Thioridazine, Amantadine. The full list is on the Memantine-donepezil page.
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