Drug interactions
Givinostat + Pramipexole
Severity: Minor
Givinostat and Pramipexole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pramipexole is eliminated largely by renal tubular secretion via OCT2, and givinostat may weakly inhibit this transport. Pramipexole exposure could rise slightly, increasing dopaminergic adverse effects.
What this interaction means in plain words
Givinostat and Pramipexole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Givinostat belongs to Miscellaneous; Pramipexole belongs to Cardiovascular.
Why it happens
Givinostat may inhibit renal transporters (OCT2), reducing pramipexole renal clearance.
What to do
Monitor for dopaminergic adverse effects such as nausea, dizziness and somnolence and reduce the pramipexole dose if they occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Pramipexole
- Amisulpride + Pramipexole Contraindicated
- Chlorpromazine + Pramipexole Major
- Droperidol + Pramipexole Major
- Fluphenazine + Pramipexole Major
- Haloperidol + Pramipexole Major
- Iloperidone + Pramipexole Major
Other interactions of Givinostat
- Abiraterone + Givinostat Major
- Amiodarone + Givinostat Major
- Amisulpride + Givinostat Major
- Amitriptyline + Givinostat Major
- Anagrelide + Givinostat Major
- Asenapine + Givinostat Major
Frequently asked questions
Can I take Givinostat with Pramipexole?
MediHelp rates the interaction as minor. Givinostat and Pramipexole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pramipexole is eliminated largely by renal tubular secretion via OCT2, and givinostat may weakly inhibit this transport. Pramipexole exposure could rise slightly, increasing dopaminergic adverse effects.
How serious is the interaction between Givinostat and Pramipexole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for dopaminergic adverse effects such as nausea, dizziness and somnolence and reduce the pramipexole dose if they occur.
What other medicines interact with Pramipexole?
MediHelp also lists interactions of Pramipexole with, for example, Amisulpride, Chlorpromazine, Droperidol. The full list is on the Pramipexole page.
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