Drug interactions
Givinostat + Saxagliptin-metformin
Severity: Minor
Givinostat and Saxagliptin-metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Givinostat is a weak inhibitor of renal transporters involved in metformin handling, so metformin exposure may rise slightly. The clinical effect is probably small but could matter in patients with impaired renal function.
What this interaction means in plain words
Givinostat and Saxagliptin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Givinostat belongs to Miscellaneous; Saxagliptin-metformin belongs to Endocrine.
Why it happens
Weak inhibition of renal organic cation transporters, reducing tubular secretion of metformin.
What to do
No routine dose change is needed; monitor glycemic control and renal function, and watch for gastrointestinal intolerance or signs of lactic acidosis in patients with renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Saxagliptin-metformin
Other interactions of Givinostat
- Abiraterone + Givinostat Major
- Amiodarone + Givinostat Major
- Amisulpride + Givinostat Major
- Amitriptyline + Givinostat Major
- Anagrelide + Givinostat Major
- Asenapine + Givinostat Major
Frequently asked questions
Can I take Givinostat with Saxagliptin-metformin?
MediHelp rates the interaction as minor. Givinostat and Saxagliptin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Givinostat is a weak inhibitor of renal transporters involved in metformin handling, so metformin exposure may rise slightly. The clinical effect is probably small but could matter in patients with impaired renal function.
How serious is the interaction between Givinostat and Saxagliptin-metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; monitor glycemic control and renal function, and watch for gastrointestinal intolerance or signs of lactic acidosis in patients with renal impairment.
What other medicines interact with Saxagliptin-metformin?
MediHelp also lists interactions of Saxagliptin-metformin with, for example, Atazanavir, Clozapine, Contrast media. The full list is on the Saxagliptin-metformin page.
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