Drug interactions
Givinostat + Sertraline
Severity: Major
Givinostat and Sertraline: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Givinostat can prolong the QT interval, and sertraline has a small additive effect. Together they increase the risk of ventricular arrhythmia, particularly with electrolyte abnormalities or cardiac disease.
What this interaction means in plain words
Givinostat and Sertraline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Givinostat belongs to Miscellaneous; Sertraline belongs to Central Nervous System.
Why it happens
Additive QT interval prolongation.
What to do
Obtain ECGs at baseline and during co-therapy, and keep potassium and magnesium normal. Withhold givinostat if the QTc becomes markedly prolonged and consider a different antidepressant.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Other interactions of Givinostat
- Abiraterone + Givinostat Major
- Amiodarone + Givinostat Major
- Amisulpride + Givinostat Major
- Amitriptyline + Givinostat Major
- Anagrelide + Givinostat Major
- Asenapine + Givinostat Major
Frequently asked questions
Can I take Givinostat with Sertraline?
MediHelp rates the interaction as major. Givinostat and Sertraline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Givinostat can prolong the QT interval, and sertraline has a small additive effect. Together they increase the risk of ventricular arrhythmia, particularly with electrolyte abnormalities or cardiac disease.
How serious is the interaction between Givinostat and Sertraline?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain ECGs at baseline and during co-therapy, and keep potassium and magnesium normal. Withhold givinostat if the QTc becomes markedly prolonged and consider a different antidepressant.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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