Drug interactions
Givinostat + Simvastatin
Severity: Moderate
Givinostat and Simvastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Givinostat is a weak CYP3A4 inhibitor and may modestly increase simvastatin concentrations. This could raise the risk of statin-related muscle toxicity, particularly at higher simvastatin doses.
What this interaction means in plain words
Givinostat and Simvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Givinostat belongs to Miscellaneous; Simvastatin belongs to Cardiovascular.
Why it happens
Weak inhibition of CYP3A4 by givinostat reduces simvastatin metabolism.
What to do
Use the lowest effective simvastatin dose and monitor for myalgia or weakness. Consider an alternative statin if symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Givinostat and Simvastatin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Simvastatin
- Atazanavir + Simvastatin Contraindicated
- Clarithromycin + Simvastatin Contraindicated
- Cobicistat + Simvastatin Contraindicated
- Cyclosporine + Simvastatin Contraindicated
- Cyclosporin + Simvastatin Contraindicated
- Danazol + Simvastatin Contraindicated
Other interactions of Givinostat
- Abiraterone + Givinostat Major
- Amiodarone + Givinostat Major
- Amisulpride + Givinostat Major
- Amitriptyline + Givinostat Major
- Anagrelide + Givinostat Major
- Asenapine + Givinostat Major
Frequently asked questions
Can I take Givinostat with Simvastatin?
MediHelp rates the interaction as moderate. Givinostat and Simvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Givinostat is a weak CYP3A4 inhibitor and may modestly increase simvastatin concentrations. This could raise the risk of statin-related muscle toxicity, particularly at higher simvastatin doses.
How serious is the interaction between Givinostat and Simvastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective simvastatin dose and monitor for myalgia or weakness. Consider an alternative statin if symptoms develop.
What other medicines interact with Simvastatin?
MediHelp also lists interactions of Simvastatin with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Simvastatin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
