Drug interactions
Givinostat + Valproic acid
Severity: Moderate
Givinostat and Valproic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valproate is not primarily a CYP3A4 substrate, so givinostat's weak CYP3A4 inhibition is unlikely to change valproate exposure meaningfully. Givinostat may however add to thrombocytopenia risk, which valproate also carries.
What this interaction means in plain words
Givinostat and Valproic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Givinostat belongs to Miscellaneous; Valproic acid belongs to Central Nervous System.
Why it happens
Valproate is minimally CYP3A4 dependent; the combination mainly adds hematologic toxicity (thrombocytopenia) pharmacodynamically.
What to do
Monitor platelet counts regularly during combined use. Dose changes of valproate are not needed for the CYP3A4 effect.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Valproic acid
- Ertapenem + Valproic acid Contraindicated
- Imipenem / cilastatin / relebactam + Valproic acid Contraindicated
- Imipenem / cilastatin + Valproic acid Contraindicated
- Meropenem / vaborbactam + Valproic acid Contraindicated
- Meropenem + Valproic acid Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Valproic acid Major
Other interactions of Givinostat
- Abiraterone + Givinostat Major
- Amiodarone + Givinostat Major
- Amisulpride + Givinostat Major
- Amitriptyline + Givinostat Major
- Anagrelide + Givinostat Major
- Asenapine + Givinostat Major
Frequently asked questions
Can I take Givinostat with Valproic acid?
MediHelp rates the interaction as moderate. Givinostat and Valproic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Valproate is not primarily a CYP3A4 substrate, so givinostat's weak CYP3A4 inhibition is unlikely to change valproate exposure meaningfully. Givinostat may however add to thrombocytopenia risk, which valproate also carries.
How serious is the interaction between Givinostat and Valproic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor platelet counts regularly during combined use. Dose changes of valproate are not needed for the CYP3A4 effect.
What other medicines interact with Valproic acid?
MediHelp also lists interactions of Valproic acid with, for example, Ertapenem, Imipenem / cilastatin / relebactam, Imipenem / cilastatin. The full list is on the Valproic acid page.
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