Drug interactions
Glasdegib + Ipratropium-salbutamol
Severity: Moderate
Glasdegib and Ipratropium-salbutamol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glasdegib can prolong the QT interval, and salbutamol may add to this, particularly at high doses or with hypokalemia. The risk is greater in patients with other QT risk factors.
What this interaction means in plain words
Glasdegib and Ipratropium-salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glasdegib belongs to Oncology; Ipratropium-salbutamol belongs to Respiratory.
Why it happens
Additive QT prolongation, with beta-agonist-induced hypokalemia.
What to do
Monitor ECG and electrolytes, and correct potassium and magnesium abnormalities before and during co-use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ipratropium-salbutamol
Other interactions of Glasdegib
- Amiodarone + Glasdegib Major
- Amisulpride + Glasdegib Major
- Amobarbital + Glasdegib Major
- Anagrelide + Glasdegib Major
- Apalutamide + Glasdegib Major
- Asenapine + Glasdegib Major
Frequently asked questions
Can I take Glasdegib with Ipratropium-salbutamol?
MediHelp rates the interaction as moderate. Glasdegib and Ipratropium-salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glasdegib can prolong the QT interval, and salbutamol may add to this, particularly at high doses or with hypokalemia. The risk is greater in patients with other QT risk factors.
How serious is the interaction between Glasdegib and Ipratropium-salbutamol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes, and correct potassium and magnesium abnormalities before and during co-use.
What other medicines interact with Ipratropium-salbutamol?
MediHelp also lists interactions of Ipratropium-salbutamol with, for example, Amisulpride, Arsenic trioxide, Carvedilol. The full list is on the Ipratropium-salbutamol page.
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