Drug interactions
Glasdegib + Sertraline
Severity: Moderate
Glasdegib and Sertraline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glasdegib can prolong the QT interval, and sertraline adds a modest QT effect. The combination raises the risk of torsades de pointes, particularly with electrolyte disturbances or cardiac disease.
What this interaction means in plain words
Glasdegib and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glasdegib belongs to Oncology; Sertraline belongs to Central Nervous System.
Why it happens
Additive QT interval prolongation.
What to do
Check the ECG and electrolytes at baseline and at least once in the first weeks of treatment, then as clinically indicated. Consider an alternative antidepressant if the QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Other interactions of Glasdegib
- Amiodarone + Glasdegib Major
- Amisulpride + Glasdegib Major
- Amobarbital + Glasdegib Major
- Anagrelide + Glasdegib Major
- Apalutamide + Glasdegib Major
- Asenapine + Glasdegib Major
Frequently asked questions
Can I take Glasdegib with Sertraline?
MediHelp rates the interaction as moderate. Glasdegib and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glasdegib can prolong the QT interval, and sertraline adds a modest QT effect. The combination raises the risk of torsades de pointes, particularly with electrolyte disturbances or cardiac disease.
How serious is the interaction between Glasdegib and Sertraline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check the ECG and electrolytes at baseline and at least once in the first weeks of treatment, then as clinically indicated. Consider an alternative antidepressant if the QTc becomes markedly prolonged.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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