Drug interactions
Glecaprevir / pibrentasvir + Itraconazole
Severity: Moderate
Glecaprevir / pibrentasvir and Itraconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole can increase glecaprevir and pibrentasvir concentrations because both are substrates of P-glycoprotein and glecaprevir is also partly metabolized by CYP3A4. Higher exposure may increase adverse effects such as hepatic enzyme elevation or gastrointestinal symptoms.
What this interaction means in plain words
Glecaprevir / pibrentasvir and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Itraconazole inhibits intestinal P-glycoprotein and CYP3A4, reducing first-pass clearance of the antivirals.
What to do
Monitor liver function tests and tolerability during the HCV course. No empirical dose change is established.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Frequently asked questions
Can I take Glecaprevir / pibrentasvir with Itraconazole?
MediHelp rates the interaction as moderate. Glecaprevir / pibrentasvir and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Itraconazole can increase glecaprevir and pibrentasvir concentrations because both are substrates of P-glycoprotein and glecaprevir is also partly metabolized by CYP3A4. Higher exposure may increase adverse effects such as hepatic enzyme elevation or gastrointestinal symptoms.
How serious is the interaction between Glecaprevir / pibrentasvir and Itraconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver function tests and tolerability during the HCV course. No empirical dose change is established.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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