Drug interactions
Glecaprevir / pibrentasvir + Loperamide
Severity: Moderate
Glecaprevir / pibrentasvir and Loperamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glecaprevir and pibrentasvir inhibit P-glycoprotein, which may raise loperamide exposure. Increased levels could enhance constipating and, rarely, central or cardiac effects.
What this interaction means in plain words
Glecaprevir / pibrentasvir and Loperamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
P-gp inhibition decreases loperamide efflux and increases its absorption and CNS penetration.
What to do
Use standard short-course loperamide at the lowest effective dose and monitor for constipation, sedation and palpitations.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Loperamide
Frequently asked questions
Can I take Glecaprevir / pibrentasvir with Loperamide?
MediHelp rates the interaction as moderate. Glecaprevir / pibrentasvir and Loperamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glecaprevir and pibrentasvir inhibit P-glycoprotein, which may raise loperamide exposure. Increased levels could enhance constipating and, rarely, central or cardiac effects.
How serious is the interaction between Glecaprevir / pibrentasvir and Loperamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use standard short-course loperamide at the lowest effective dose and monitor for constipation, sedation and palpitations.
What other medicines interact with Loperamide?
MediHelp also lists interactions of Loperamide with, for example, Amiodarone, Amisulpride, Anagrelide. The full list is on the Loperamide page.
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