Drug interactions
Glecaprevir / pibrentasvir + Lovastatin
Severity: Major
Glecaprevir / pibrentasvir and Lovastatin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glecaprevir and pibrentasvir raise statin exposure and increase the risk of myopathy including rhabdomyolysis. Labeling does not recommend use with lovastatin.
What this interaction means in plain words
Glecaprevir / pibrentasvir and Lovastatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Inhibition of OATP1B1/1B3 (and CYP3A4 and BCRP to some extent) increases lovastatin exposure.
What to do
Avoid coadministration; withhold lovastatin during HCV therapy or switch to a statin with dose limits per labeling. Monitor for muscle symptoms.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Lovastatin
- Atazanavir + Lovastatin Contraindicated
- Clarithromycin + Lovastatin Contraindicated
- Cobicistat + Lovastatin Contraindicated
- Conivaptan + Lovastatin Contraindicated
- Darunavir + Lovastatin Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Lovastatin Contraindicated
Frequently asked questions
Can I take Glecaprevir / pibrentasvir with Lovastatin?
MediHelp rates the interaction as major. Glecaprevir / pibrentasvir and Lovastatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Glecaprevir and pibrentasvir raise statin exposure and increase the risk of myopathy including rhabdomyolysis. Labeling does not recommend use with lovastatin.
How serious is the interaction between Glecaprevir / pibrentasvir and Lovastatin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid coadministration; withhold lovastatin during HCV therapy or switch to a statin with dose limits per labeling. Monitor for muscle symptoms.
What other medicines interact with Lovastatin?
MediHelp also lists interactions of Lovastatin with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Lovastatin page.
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