Drug interactions
Glecaprevir / pibrentasvir + Mefloquine
Severity: Minor
Glecaprevir / pibrentasvir and Mefloquine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both mefloquine and glecaprevir/pibrentasvir interact with P-glycoprotein, so each may raise the other's exposure. The clinical significance is uncertain and likely modest.
What this interaction means in plain words
Glecaprevir / pibrentasvir and Mefloquine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Mutual P-glycoprotein inhibition or competition.
What to do
No dose adjustment is usually needed. Monitor for adverse effects of either drug.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Mefloquine
- Arsenic trioxide + Mefloquine Contraindicated
- Dronedarone + Mefloquine Contraindicated
- Ibutilide + Mefloquine Contraindicated
- Levoketoconazole + Mefloquine Contraindicated
- Mefloquine + Nilotinib Contraindicated
- Mefloquine + Pimozide Contraindicated
Frequently asked questions
Can I take Glecaprevir / pibrentasvir with Mefloquine?
MediHelp rates the interaction as minor. Glecaprevir / pibrentasvir and Mefloquine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both mefloquine and glecaprevir/pibrentasvir interact with P-glycoprotein, so each may raise the other's exposure. The clinical significance is uncertain and likely modest.
How serious is the interaction between Glecaprevir / pibrentasvir and Mefloquine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually needed. Monitor for adverse effects of either drug.
What other medicines interact with Mefloquine?
MediHelp also lists interactions of Mefloquine with, for example, Arsenic trioxide, Dronedarone, Ibutilide. The full list is on the Mefloquine page.
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