Drug interactions
Glecaprevir / pibrentasvir + Nitrofurantoin
Severity: Minor
Glecaprevir / pibrentasvir and Nitrofurantoin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glecaprevir and pibrentasvir inhibit BCRP and may modestly increase exposure to BCRP substrates. Nitrofurantoin could therefore reach slightly higher levels, with limited expected clinical consequence over a short course.
What this interaction means in plain words
Glecaprevir / pibrentasvir and Nitrofurantoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of intestinal BCRP efflux by glecaprevir and pibrentasvir, not a change in metabolism.
What to do
No routine dose change is needed. Monitor for nitrofurantoin adverse effects, especially in renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nitrofurantoin
Frequently asked questions
Can I take Glecaprevir / pibrentasvir with Nitrofurantoin?
MediHelp rates the interaction as minor. Glecaprevir / pibrentasvir and Nitrofurantoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Glecaprevir and pibrentasvir inhibit BCRP and may modestly increase exposure to BCRP substrates. Nitrofurantoin could therefore reach slightly higher levels, with limited expected clinical consequence over a short course.
How serious is the interaction between Glecaprevir / pibrentasvir and Nitrofurantoin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Monitor for nitrofurantoin adverse effects, especially in renal impairment.
What other medicines interact with Nitrofurantoin?
MediHelp also lists interactions of Nitrofurantoin with, for example, Pexidartinib, Pretomanid, Aluminum hydroxide. The full list is on the Nitrofurantoin page.
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