Drug interactions
Glecaprevir / pibrentasvir + Paliperidone
Severity: Minor
Glecaprevir / pibrentasvir and Paliperidone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both glecaprevir and pibrentasvir inhibit P-glycoprotein, and paliperidone is a P-gp substrate, so paliperidone exposure may increase modestly. This could heighten dose-related adverse effects such as sedation, extrapyramidal symptoms and QT effects.
What this interaction means in plain words
Glecaprevir / pibrentasvir and Paliperidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of P-glycoprotein efflux by glecaprevir and pibrentasvir raises paliperidone absorption and reduces its elimination.
What to do
No routine dose change is needed, but monitor for increased adverse effects during the hepatitis C treatment course. Reduce the paliperidone dose if toxicity appears.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Paliperidone
- Ibutilide + Paliperidone Contraindicated
- Paliperidone + Pimozide Contraindicated
- Paliperidone + Vandetanib Contraindicated
- Adagrasib + Paliperidone Major
- Amiodarone + Paliperidone Major
- Amisulpride + Paliperidone Major
Frequently asked questions
Can I take Glecaprevir / pibrentasvir with Paliperidone?
MediHelp rates the interaction as minor. Glecaprevir / pibrentasvir and Paliperidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both glecaprevir and pibrentasvir inhibit P-glycoprotein, and paliperidone is a P-gp substrate, so paliperidone exposure may increase modestly. This could heighten dose-related adverse effects such as sedation, extrapyramidal symptoms and QT effects.
How serious is the interaction between Glecaprevir / pibrentasvir and Paliperidone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed, but monitor for increased adverse effects during the hepatitis C treatment course. Reduce the paliperidone dose if toxicity appears.
What other medicines interact with Paliperidone?
MediHelp also lists interactions of Paliperidone with, for example, Ibutilide, Pimozide, Vandetanib. The full list is on the Paliperidone page.
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