Drug interactions
Glecaprevir / pibrentasvir + Pravastatin
Severity: Moderate
Glecaprevir / pibrentasvir and Pravastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glecaprevir/pibrentasvir raises pravastatin exposure, increasing the risk of statin-related muscle toxicity including myopathy and rhabdomyolysis. The effect is clinically relevant at standard pravastatin doses.
What this interaction means in plain words
Glecaprevir / pibrentasvir and Pravastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of hepatic uptake transporters (OATP1B1/1B3) and possibly BCRP by glecaprevir and pibrentasvir reduces pravastatin clearance.
What to do
Reduce the pravastatin dose by about half while the HCV regimen is given. Counsel the patient to report unexplained muscle pain or weakness, and check CK if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pravastatin
Frequently asked questions
Can I take Glecaprevir / pibrentasvir with Pravastatin?
MediHelp rates the interaction as moderate. Glecaprevir / pibrentasvir and Pravastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glecaprevir/pibrentasvir raises pravastatin exposure, increasing the risk of statin-related muscle toxicity including myopathy and rhabdomyolysis. The effect is clinically relevant at standard pravastatin doses.
How serious is the interaction between Glecaprevir / pibrentasvir and Pravastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the pravastatin dose by about half while the HCV regimen is given. Counsel the patient to report unexplained muscle pain or weakness, and check CK if symptoms occur.
What other medicines interact with Pravastatin?
MediHelp also lists interactions of Pravastatin with, for example, Cyclosporine, Cyclosporin, Gemfibrozil. The full list is on the Pravastatin page.
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