Drug interactions
Glecaprevir / pibrentasvir + Ribociclib
Severity: Moderate
Glecaprevir / pibrentasvir and Ribociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glecaprevir and pibrentasvir are inhibitors of P-gp, BCRP and OATP, and ribociclib is a substrate of P-gp and BCRP. Ribociclib exposure could rise, increasing QT prolongation and neutropenia risk, while the effect of ribociclib on glecaprevir/pibrentasvir is minor.
What this interaction means in plain words
Glecaprevir / pibrentasvir and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Transporter inhibition by glecaprevir/pibrentasvir may increase ribociclib exposure, with minor CYP3A4 contribution.
What to do
Monitor ECG, electrolytes and blood counts during the short HCV course. Reduce the ribociclib dose if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Glecaprevir / pibrentasvir with Ribociclib?
MediHelp rates the interaction as moderate. Glecaprevir / pibrentasvir and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glecaprevir and pibrentasvir are inhibitors of P-gp, BCRP and OATP, and ribociclib is a substrate of P-gp and BCRP. Ribociclib exposure could rise, increasing QT prolongation and neutropenia risk, while the effect of ribociclib on glecaprevir/pibrentasvir is minor.
How serious is the interaction between Glecaprevir / pibrentasvir and Ribociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG, electrolytes and blood counts during the short HCV course. Reduce the ribociclib dose if toxicity occurs.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
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