Drug interactions
Glecaprevir / pibrentasvir + Rosiglitazone
Severity: Minor
Glecaprevir / pibrentasvir and Rosiglitazone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glecaprevir and pibrentasvir are OATP1B1/1B3 substrates and inhibitors of P-gp, BCRP and OATP. Rosiglitazone is not a recognized significant inhibitor of these transporters, so a meaningful rise in their levels is not expected. Glecaprevir/pibrentasvir could possibly raise rosiglitazone exposure, but the effect is unestablished.
What this interaction means in plain words
Glecaprevir / pibrentasvir and Rosiglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible transporter-mediated interaction; not well established.
What to do
No dose change is required. Monitor blood glucose when hepatitis C therapy is started.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rosiglitazone
- Insulin aspart protamine / insulin aspart + Rosiglitazone Major
- Insulin aspart-insulin aspart protamine + Rosiglitazone Major
- Insulin aspart + Rosiglitazone Major
- Insulin degludec / insulin aspart + Rosiglitazone Major
- Insulin degludec-insulin aspart + Rosiglitazone Major
- Insulin degludec-liraglutide + Rosiglitazone Major
Frequently asked questions
Can I take Glecaprevir / pibrentasvir with Rosiglitazone?
MediHelp rates the interaction as minor. Glecaprevir / pibrentasvir and Rosiglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Glecaprevir and pibrentasvir are OATP1B1/1B3 substrates and inhibitors of P-gp, BCRP and OATP. Rosiglitazone is not a recognized significant inhibitor of these transporters, so a meaningful rise in their levels is not expected. Glecaprevir/pibrentasvir could possibly raise rosiglitazone exposure, but the effect is unestablished.
How serious is the interaction between Glecaprevir / pibrentasvir and Rosiglitazone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is required. Monitor blood glucose when hepatitis C therapy is started.
What other medicines interact with Rosiglitazone?
MediHelp also lists interactions of Rosiglitazone with, for example, Insulin aspart protamine / insulin aspart, Insulin aspart-insulin aspart protamine, Insulin aspart. The full list is on the Rosiglitazone page.
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