Drug interactions
Glecaprevir / pibrentasvir + Rosuvastatin
Severity: Major
Glecaprevir / pibrentasvir and Rosuvastatin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glecaprevir and pibrentasvir markedly increase rosuvastatin concentrations. This raises the risk of myopathy and rhabdomyolysis.
What this interaction means in plain words
Glecaprevir / pibrentasvir and Rosuvastatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Inhibition of OATP1B1/1B3 and BCRP transporters increases rosuvastatin exposure.
What to do
Do not exceed rosuvastatin 10 mg daily during co-administration and monitor for muscle symptoms.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Rosuvastatin
Frequently asked questions
Can I take Glecaprevir / pibrentasvir with Rosuvastatin?
MediHelp rates the interaction as major. Glecaprevir / pibrentasvir and Rosuvastatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Glecaprevir and pibrentasvir markedly increase rosuvastatin concentrations. This raises the risk of myopathy and rhabdomyolysis.
How serious is the interaction between Glecaprevir / pibrentasvir and Rosuvastatin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not exceed rosuvastatin 10 mg daily during co-administration and monitor for muscle symptoms.
What other medicines interact with Rosuvastatin?
MediHelp also lists interactions of Rosuvastatin with, for example, Atazanavir, Cyclosporine, Cyclosporin. The full list is on the Rosuvastatin page.
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