Drug interactions
Glecaprevir / pibrentasvir + Sirolimus
Severity: Moderate
Glecaprevir / pibrentasvir and Sirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glecaprevir and pibrentasvir inhibit P-gp, which can increase sirolimus absorption and exposure. Higher levels raise the risk of sirolimus toxicity.
What this interaction means in plain words
Glecaprevir / pibrentasvir and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of intestinal P-glycoprotein (and possibly CYP3A4) increases sirolimus bioavailability.
What to do
Monitor sirolimus trough levels during and after the antiviral course and reduce the dose if concentrations rise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Frequently asked questions
Can I take Glecaprevir / pibrentasvir with Sirolimus?
MediHelp rates the interaction as moderate. Glecaprevir / pibrentasvir and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glecaprevir and pibrentasvir inhibit P-gp, which can increase sirolimus absorption and exposure. Higher levels raise the risk of sirolimus toxicity.
How serious is the interaction between Glecaprevir / pibrentasvir and Sirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sirolimus trough levels during and after the antiviral course and reduce the dose if concentrations rise.
What other medicines interact with Sirolimus?
MediHelp also lists interactions of Sirolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Sirolimus page.
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