Drug interactions
Glecaprevir / pibrentasvir + Sofosbuvir-velpatasvir-voxilaprevir
Severity: Major
Glecaprevir / pibrentasvir and Sofosbuvir-velpatasvir-voxilaprevir: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
These are two different pangenotypic HCV regimens and are not meant to be combined. Glecaprevir and pibrentasvir inhibit P-gp, BCRP and OATP1B1/3, raising velpatasvir and voxilaprevir exposure, with additive toxicity and no therapeutic benefit.
What this interaction means in plain words
Glecaprevir / pibrentasvir and Sofosbuvir-velpatasvir-voxilaprevir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Inhibition of P-gp, BCRP and OATP1B1/3 by glecaprevir and pibrentasvir increases exposure of velpatasvir and voxilaprevir.
What to do
Avoid concurrent use of the two regimens. Choose a single regimen suited to the patient's genotype and treatment history.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Sofosbuvir-velpatasvir-voxilaprevir
- Fosphenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Phenobarbital + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Phenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Rifampin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
Frequently asked questions
Can I take Glecaprevir / pibrentasvir with Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp rates the interaction as major. Glecaprevir / pibrentasvir and Sofosbuvir-velpatasvir-voxilaprevir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. These are two different pangenotypic HCV regimens and are not meant to be combined. Glecaprevir and pibrentasvir inhibit P-gp, BCRP and OATP1B1/3, raising velpatasvir and voxilaprevir exposure, with additive toxicity and no therapeutic benefit.
How serious is the interaction between Glecaprevir / pibrentasvir and Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of the two regimens. Choose a single regimen suited to the patient's genotype and treatment history.
What other medicines interact with Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp also lists interactions of Sofosbuvir-velpatasvir-voxilaprevir with, for example, Fosphenytoin, Phenobarbital, Phenytoin. The full list is on the Sofosbuvir-velpatasvir-voxilaprevir page.
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