Drug interactions
Glecaprevir / pibrentasvir + Voriconazole
Severity: Minor
Glecaprevir / pibrentasvir and Voriconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole may increase glecaprevir and pibrentasvir concentrations, though the combination has not been well studied. The increase is generally of limited clinical concern given the drugs' safety margin.
What this interaction means in plain words
Glecaprevir / pibrentasvir and Voriconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Voriconazole inhibits CYP3A4 and possibly P-glycoprotein, modestly reducing clearance of the HCV agents.
What to do
No dose adjustment is routinely required; monitor liver function and for gastrointestinal or hepatic adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Frequently asked questions
Can I take Glecaprevir / pibrentasvir with Voriconazole?
MediHelp rates the interaction as minor. Glecaprevir / pibrentasvir and Voriconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Voriconazole may increase glecaprevir and pibrentasvir concentrations, though the combination has not been well studied. The increase is generally of limited clinical concern given the drugs' safety margin.
How serious is the interaction between Glecaprevir / pibrentasvir and Voriconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is routinely required; monitor liver function and for gastrointestinal or hepatic adverse effects.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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