Drug interactions
Glibenclamide + Iloperidone
Severity: Moderate
Glibenclamide and Iloperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone, like other atypical antipsychotics, can cause weight gain, insulin resistance and hyperglycemia, which can make diabetes harder to control in patients taking glyburide.
What this interaction means in plain words
Glibenclamide and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glibenclamide belongs to Endocrine; Iloperidone belongs to Central Nervous System.
Why it happens
Antipsychotic-induced metabolic effects oppose the glucose-lowering action of glyburide.
What to do
Monitor fasting glucose and HbA1c at baseline and periodically, and adjust antidiabetic therapy if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glibenclamide
- Bosentan + Glibenclamide Contraindicated
- Cholic acid + Glibenclamide Major
- Ciprofloxacin + Glibenclamide Major
- Clarithromycin + Glibenclamide Major
- Fluconazole + Glibenclamide Major
- Glibenclamide + Insulin degludec-liraglutide Major
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Glibenclamide with Iloperidone?
MediHelp rates the interaction as moderate. Glibenclamide and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iloperidone, like other atypical antipsychotics, can cause weight gain, insulin resistance and hyperglycemia, which can make diabetes harder to control in patients taking glyburide.
How serious is the interaction between Glibenclamide and Iloperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor fasting glucose and HbA1c at baseline and periodically, and adjust antidiabetic therapy if control worsens.
What other medicines interact with Glibenclamide?
MediHelp also lists interactions of Glibenclamide with, for example, Bosentan, Cholic acid, Ciprofloxacin. The full list is on the Glibenclamide page.
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