Drug interactions
Glibenclamide + Liraglutide
Severity: Moderate
Glibenclamide and Liraglutide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining liraglutide with glyburide increases the risk of hypoglycemia, which can be severe. The risk is highest at initiation and during dose escalation of liraglutide.
What this interaction means in plain words
Glibenclamide and Liraglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glibenclamide belongs to Endocrine; Liraglutide belongs to Endocrine.
Why it happens
Additive pharmacodynamic effect of GLP-1 receptor-mediated insulin secretion and sulfonylurea-induced insulin release.
What to do
Consider reducing the glyburide dose when starting liraglutide. Monitor blood glucose closely during titration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glibenclamide
- Bosentan + Glibenclamide Contraindicated
- Cholic acid + Glibenclamide Major
- Ciprofloxacin + Glibenclamide Major
- Clarithromycin + Glibenclamide Major
- Fluconazole + Glibenclamide Major
- Glibenclamide + Insulin degludec-liraglutide Major
Other interactions of Liraglutide
Frequently asked questions
Can I take Glibenclamide with Liraglutide?
MediHelp rates the interaction as moderate. Glibenclamide and Liraglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining liraglutide with glyburide increases the risk of hypoglycemia, which can be severe. The risk is highest at initiation and during dose escalation of liraglutide.
How serious is the interaction between Glibenclamide and Liraglutide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the glyburide dose when starting liraglutide. Monitor blood glucose closely during titration.
What other medicines interact with Glibenclamide?
MediHelp also lists interactions of Glibenclamide with, for example, Bosentan, Cholic acid, Ciprofloxacin. The full list is on the Glibenclamide page.
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