Drug interactions
Glibenclamide + Lixisenatide
Severity: Moderate
Glibenclamide and Lixisenatide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lixisenatide improves glucose-dependent insulin secretion and, when added to a sulfonylurea such as glyburide, raises the risk of hypoglycemia. Glyburide's own insulin-releasing effect is independent of glucose, so the additive effect can be clinically important. Delayed gastric emptying from lixisenatide may also change the timing of glucose excursions.
What this interaction means in plain words
Glibenclamide and Lixisenatide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glibenclamide belongs to Endocrine; Lixisenatide belongs to Endocrine.
Why it happens
Additive pharmacodynamic effect on insulin secretion from a GLP-1 receptor agonist and a sulfonylurea.
What to do
Consider lowering the glyburide dose when lixisenatide is started. Monitor blood glucose and counsel the patient on recognising hypoglycemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glibenclamide
- Bosentan + Glibenclamide Contraindicated
- Cholic acid + Glibenclamide Major
- Ciprofloxacin + Glibenclamide Major
- Clarithromycin + Glibenclamide Major
- Fluconazole + Glibenclamide Major
- Glibenclamide + Insulin degludec-liraglutide Major
Other interactions of Lixisenatide
Frequently asked questions
Can I take Glibenclamide with Lixisenatide?
MediHelp rates the interaction as moderate. Glibenclamide and Lixisenatide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lixisenatide improves glucose-dependent insulin secretion and, when added to a sulfonylurea such as glyburide, raises the risk of hypoglycemia. Glyburide's own insulin-releasing effect is independent of glucose, so the additive effect can be clinically important. Delayed gastric emptying from lixisenatide may also change the timing of glucose excursions.
How serious is the interaction between Glibenclamide and Lixisenatide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider lowering the glyburide dose when lixisenatide is started. Monitor blood glucose and counsel the patient on recognising hypoglycemia.
What other medicines interact with Glibenclamide?
MediHelp also lists interactions of Glibenclamide with, for example, Bosentan, Cholic acid, Ciprofloxacin. The full list is on the Glibenclamide page.
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