Drug interactions
Glibenclamide + Lornoxicam
Severity: Moderate
Glibenclamide and Lornoxicam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may potentiate the hypoglycemic effect of sulfonylureas, and hypoglycemia has been reported with some combinations. The evidence for lornoxicam specifically is limited and the effect is generally modest.
What this interaction means in plain words
Glibenclamide and Lornoxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glibenclamide belongs to Endocrine; Lornoxicam belongs to Musculoskeletal.
Why it happens
Possible displacement from protein binding and/or reduced clearance of the sulfonylurea; the mechanism is not firmly established.
What to do
Monitor blood glucose when lornoxicam is started or stopped. Reduce the glyburide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glibenclamide
- Bosentan + Glibenclamide Contraindicated
- Cholic acid + Glibenclamide Major
- Ciprofloxacin + Glibenclamide Major
- Clarithromycin + Glibenclamide Major
- Fluconazole + Glibenclamide Major
- Glibenclamide + Insulin degludec-liraglutide Major
Other interactions of Lornoxicam
Frequently asked questions
Can I take Glibenclamide with Lornoxicam?
MediHelp rates the interaction as moderate. Glibenclamide and Lornoxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs may potentiate the hypoglycemic effect of sulfonylureas, and hypoglycemia has been reported with some combinations. The evidence for lornoxicam specifically is limited and the effect is generally modest.
How serious is the interaction between Glibenclamide and Lornoxicam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when lornoxicam is started or stopped. Reduce the glyburide dose if hypoglycemia occurs.
What other medicines interact with Glibenclamide?
MediHelp also lists interactions of Glibenclamide with, for example, Bosentan, Cholic acid, Ciprofloxacin. The full list is on the Glibenclamide page.
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