Drug interactions
Glibenclamide + Osimertinib
Severity: Minor
Glibenclamide and Osimertinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Osimertinib inhibits BCRP in vitro and in clinical studies, and glyburide is partly handled by this transporter. Exposure to glyburide could increase slightly, with a greater chance of hypoglycemia. The clinical significance is likely small.
What this interaction means in plain words
Glibenclamide and Osimertinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glibenclamide belongs to Endocrine; Osimertinib belongs to Oncology.
Why it happens
Osimertinib inhibits BCRP-mediated efflux of glyburide.
What to do
Monitor blood glucose after starting osimertinib. Lower the glyburide dose if hypoglycemia appears.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glibenclamide
- Bosentan + Glibenclamide Contraindicated
- Cholic acid + Glibenclamide Major
- Ciprofloxacin + Glibenclamide Major
- Clarithromycin + Glibenclamide Major
- Fluconazole + Glibenclamide Major
- Glibenclamide + Insulin degludec-liraglutide Major
Other interactions of Osimertinib
Frequently asked questions
Can I take Glibenclamide with Osimertinib?
MediHelp rates the interaction as minor. Glibenclamide and Osimertinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Osimertinib inhibits BCRP in vitro and in clinical studies, and glyburide is partly handled by this transporter. Exposure to glyburide could increase slightly, with a greater chance of hypoglycemia. The clinical significance is likely small.
How serious is the interaction between Glibenclamide and Osimertinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting osimertinib. Lower the glyburide dose if hypoglycemia appears.
What other medicines interact with Glibenclamide?
MediHelp also lists interactions of Glibenclamide with, for example, Bosentan, Cholic acid, Ciprofloxacin. The full list is on the Glibenclamide page.
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