Drug interactions
Gliclazide + Ketoprofen
Severity: Moderate
Gliclazide and Ketoprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketoprofen may enhance the glucose-lowering effect of gliclazide, with a risk of hypoglycemia. NSAIDs may also impair renal function in diabetic patients.
What this interaction means in plain words
Gliclazide and Ketoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gliclazide belongs to Endocrine; Ketoprofen belongs to Musculoskeletal.
Why it happens
Possible protein-binding displacement and reduced renal clearance; not firmly established.
What to do
Monitor blood glucose when ketoprofen is started or stopped. Adjust the gliclazide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gliclazide
Other interactions of Ketoprofen
- Ketoprofen + Ketorolac Contraindicated
- Ketoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Ketoprofen Major
- Acemetacin + Ketoprofen Major
- Acetylsalicylic acid + Ketoprofen Major
- Alteplase + Ketoprofen Major
Frequently asked questions
Can I take Gliclazide with Ketoprofen?
MediHelp rates the interaction as moderate. Gliclazide and Ketoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ketoprofen may enhance the glucose-lowering effect of gliclazide, with a risk of hypoglycemia. NSAIDs may also impair renal function in diabetic patients.
How serious is the interaction between Gliclazide and Ketoprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when ketoprofen is started or stopped. Adjust the gliclazide dose if hypoglycemia occurs.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
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