Drug interactions
Gliclazide + Linezolid
Severity: Moderate
Gliclazide and Linezolid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Linezolid has been associated with hypoglycemia in diabetic patients taking insulin or oral antidiabetics. Because gliclazide stimulates insulin release, the risk may be increased.
What this interaction means in plain words
Gliclazide and Linezolid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gliclazide belongs to Endocrine; Linezolid belongs to Anti Bacterial.
Why it happens
Not clearly established; may involve weak MAO inhibition or additive glucose lowering.
What to do
Monitor blood glucose during linezolid therapy. Reduce the gliclazide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gliclazide
Other interactions of Linezolid
- Amoxapine + Linezolid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Benzphetamine + Linezolid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion + Linezolid Contraindicated
Frequently asked questions
Can I take Gliclazide with Linezolid?
MediHelp rates the interaction as moderate. Gliclazide and Linezolid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Linezolid has been associated with hypoglycemia in diabetic patients taking insulin or oral antidiabetics. Because gliclazide stimulates insulin release, the risk may be increased.
How serious is the interaction between Gliclazide and Linezolid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during linezolid therapy. Reduce the gliclazide dose if hypoglycemia occurs.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
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